Everyone knows the brain is a rather vital part of your anatomy, however it’s thought of as a rather different and special organ. It’s cased in its own hard bone shell, has an elaborate blood-brain barrier to keep foreign chemicals out, and has no pain or sensory nerves. However beyond these protections that keep it humming under tough circumstances, there is now evidence that it has it’s own brand of the rest of the body’s immune system.
From Science Daily:
"In 2008, researchers at Rockefeller University first identified a population of dendritic cells, the sentinels of the immune system, that was native to the brain. Now they have shown that these cells are not likely sleeping on the job. In experiments published recently in Proceedings of the National Academy of Sciences and Brain Behavior and Immunity, the researchers show that these brain dendritic cells can muster the immune system’s soldier T cells when confronted by certain threats. They also show that, unlike dendritic cells from elsewhere in the body, brain dendritic cells line up along the periphery of stroke-damaged brain tissue, perhaps as a barricade protecting the healthy cells outside…
Dendritic cells capture and process foreign substances called antigens before presenting them to T cells, which multiply and attack the invaders. To test their activity in the brain, the researchers, led by Rockefeller graduate Andres Gottfried-Blackmore, now a student at Weill Cornell Medical College, injected a mouse brain with interferon-γ, an immune-response molecule produced during specific inflammatory responses. They found that the interferon increased the number of brain dendritic cells without recruiting dendritic cells from elsewhere in the immune system. They then exposed the dendritic cells to a model antigen called OVA, prompting a proliferation of OVA-specific T cells. The brain dendritic cells also proved far more effective at stimulating T cell proliferation in the same test than similar immune-related cells called microglia, which reside in the brain in huge numbers. The difference suggests a specialized role for brain dendritic cells.
In other experiments, led by postdoctoral fellow Jennifer Felger and in collaboration with the laboratory of Costatino Iadecola at Weill Cornell, researchers studied the response of brain dendritic cells labeled with a fluorescent protein after inducing strokes in mice. Unlike dendritic cells from elsewhere in the body, which were drawn into the stroke-damaged tissues, brain dendritic cells closed ranks around the perimeter of the damage, forming a barrier between stricken and healthy tissues.
Brain dendritic cells remain largely mysterious, but their immune-related activity suggests they play an important part in protecting the brain. The researchers are also interested in finding out what they do when they are not battling threats such as strokes or infections. “It is equally important to understand what they do when they are not defending the brain,” Bulloch says.”